In line with our results, ARL8B, Tubb2A, Polr2 sub-units, Mlf2, GNL3, and Rad23B proteins were also found enriched in the insoluble fractions of Q175 HD mice brains99 and Tubb2a in R6/2 mice100 nuclear inclusions. The gene discussed is RAD23B; the disease is Huntington disease.