For example, it has been recently demonstrated that Lewy bodies (LB) isolated from Parkinson’s disease brains or LB-like inclusions in primary neurons are composed of not only filamentous and aggregated forms of alpha-synuclein but also a complex milieu of lipids, cytoskeletal proteins, and other proteins and membranous organelles, including mitochondria and autophagosomes119–122. This evidence concerns the gene SNCA and Parkinson disease.