AFP and hepatocellular carcinoma: No remarkable relationship was found between FATP5 expression and the tumor number, maximum tumor diameter, or serum AFP level (Supplementary Fig. 2D), but the downregulation of FATP5 in HCC was significantly associated with several aggressive clinical phenotypes, such as micro- and macrovascular invasion, satellites, incomplete tumor encapsulation and poor differentiation (Fig. 1I), supporting the critical role of FATP5 in HCC invasion and metastasis.