show that HNF1A-AS1 is overexpressed in colon tissues and cell lines, and served as a ceRNA to modulate miRNA-34a expression, subsequently with repression of miR-34a/SIRT1/p53 feedback loop and activation of canonical Wnt signaling pathway in metastasis of colon cancer [45]. This evidence concerns the gene SIRT1 and malignant colon neoplasm.