Hepatocyte nuclear factor 1 homeobox A antisense RNA 1 (HNF1A-AS1), was first identified as a lncRNA that upregulated in esophageal adenocarcinoma [21], and its overexpression was drastically associated with tumor advanced-stage and unfavorable outcomes in various cancers, including oral squamous carcinoma, urothelial carcinoma of the bladder and lung carcinoma, indicating an oncogenic function of HNF1A-AS1 in tumor progression [22–24]. Here, HNF1A is linked to esophageal adenocarcinoma.