CD4 and acute myeloid leukemia: Eomes+T-betdim CD8+ T cells were increased in Batf3-/- mice after CD8α ALN-1 treatment, a phenotype described by Jia et al. to be functionally impaired and correlated with poor prognosis in acute myeloid leukemia.38 However, these results should be cautiously interpreted, as recent studies reported on the importance of T cell-intrinsic Batf3 expression during memory CD8+ T cell and TH9 CD4+ T cells development.39 40