IFN-γ has been described to enhance sensitivity of tumor endothelial cells for TNF activity and could therefore be an important mediator of this synergy.31 Indeed, on systemic administration of an anti-mouse IFN-γRI antibody in LLC-OVA+ mice, treatment with CD8α ALN-1 combined with CD13 AFR only induced complete tumor necrosis in one in five mice (figure 7J). This evidence concerns the gene IFNG and neoplasm.