Parisiadou et al. have reported that the stimulation of neuronal SERCA can increase the ER Ca2+ store followed by the less influx of extracellular calcium to the cytosol of neuro cells, which in turn increases the interactions between APP and homer proteins, and hence reduces the accumulation of the amyloid plaques and further ameliorate the symptoms of AD [50]. The gene discussed is APP; the disease is Alzheimer disease.