MAPT and Alzheimer disease: While the hypothesis that tau pathology in the LC is at the basis of the dopaminergic deficits observed in AD remains speculative, it is worth noting that the topography of dopaminergic alteration detected in our cohorts, specifically encompassing projections from the VTA and the medial portions of the SN pars compacta (Fig. 5), closely matches that of the noradrenergic projections from the LC to the midbrain dopaminergic nuclei [48].