Studies of miRNA members, miR-409, miR-379 and miR-154*, located within the delta-like 1 homolog-deiodinase, iodothyronine 3 (DLK1-DIO3) imprinted region located on human chromosome 14, have shown that these miRNAs induce tumor effects in vitro and in PC xenograft models. This evidence concerns the gene DIO3 and neoplasm.