NOS1AP and Insulin resistance: In this study, we observed that subjects with at least one C allele of the NOS1AP rs12742393 showed a smaller decrease in FPG and HOMA-IR and more obvious increase in FINS and HOMA-B levels than those with the AA genotype, which suggested that the NOS1AP rs12742393 C allele confers the poor nateglinide response through improving insulin resistance, as measured by HOMA-IR.