NOS1AP and type 2 diabetes mellitus: We observed that, T2DM patients with at least one C allele of PPARD rs2016520 (T/C) or one C allele of NOS1AP rs12742393 (A/C) may be less responsive to treatment with nateglinide, indicating that the PPARD and NOS1AP genotype may serve as nateglinide response prognosticator.