Consistent with increased IL-17A levels, we detected a significant upregulation of Cxcl1 and Mmp3 transcripts in the whole brain mRNA and a significant increase in absolute numbers of neutrophils at day 3 post-stroke in Il10−/− mice, respectively (Fig. 3D, and Additional file 1: Fig. S3B). The gene discussed is CXCL1; the disease is stroke disorder.