Hence, in the present study, according to the microarray data from GEO database, we screened a series of genes, including MYC and CXCL8, as well as the TNF signaling pathway, cytokine-cytokine receptor interaction, and IL-17 signaling pathway, related to resting mast cells which are involved meningioma pathogenesis and prognosis. This evidence concerns the gene CXCL8 and meningioma.