However, the infiltration levels of CD8 T cells (P < 0.0001), activated CD4 memory T cells (P = 0.029), and regulatory T cells (P = 0.0187) were higher in the low-risk group (Fig. 8E), which indicated that activated T cells in the TIME could inhibit the biological activity and growth of tumour cells, leading to a favourable prognosis. This evidence concerns the gene CD4 and neoplasm.