Additionally, bioinformatics analysis results further indicated that FOXD1 was involved significant pathways included KEGG Pathways in cancer, EMT, Focal adhesion, Apoptosis, TGF-beta signaling, Cell cycle etc. Consistently, previous studies have revealed that FOXD1 facilitates cell proliferation and inhibits apoptosis by promoting the expression of PIK2 in colorectal cancer [24]. This evidence concerns the gene FOXD1 and colorectal cancer.