FOXD1 and cancer: Firstly, we downloaded the FOXD1 correlated-gene chart from TCGA-HNSC on GEPIA2, filtered the correlation score > 0.2 geneset (Fig. 5A) and performing gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and the data suggests that FOXD1-positive-corrlated genes enriched in numerous cancer related biofunction and pathways such as cell-substrate junction and focal adhesion(Fig. 5B, C).