Both HDL-C/apoA-I levels and HDL-C levels were notably higher in patients with kidney insufficiency (0.83 ± 0.13 and 0.87 ± 0.11, P = 0.005 and0.93 ± 0.02 and 0.98 ± 0.02, P = 0.024).Additionally, patients were grouped by chronic kidney disease categories, and between-group analysis revealed that HDL-C/apoA-I increased as eGFR declined, and significance was presented in patients with moderately reduced kidney function (eGFR < 60 ml/min·1.73 m2; P < 0.001), as shown in Table 3 and Fig. 1. The gene discussed is APOA1; the disease is chronic kidney disease.