In our study, lower HDL-C/apoA1 was shown to be closely related to coronary artery stenosis in coronary heart disease patients with normal kidney function; however, in coronary heart disease patients with a moderately decreased eGFR, HDL-C/apoA-1 grew larger, and the original association with coronary artery stenosis was also lost. The gene discussed is APOA1; the disease is coronary artery disorder.