It is not surprising that ERAS expression (that is accompanied by the activation of the AKT pathway and other molecules leading to cell growth and division, as CCND1, —Figure 9, Figure S7 and [12]—) produces a phenotype quite similar to the overgrowth syndromes caused by the overactivation of the PIK3CA-AKT pathway, such as the Cloves, Proteus and PTEN hamartoma tumor syndromes, among others [42,43]. This evidence concerns the gene PIK3CA and overgrowth syndrome.