TGFB1 and neoplasm: Within this group, two subclasses were identified: a so-called ‘active immune response’ class that was characterised by an enrichment of IFN signatures, an overexpression of adaptive immune response genes and better survival (i.e., I–I), and a so-called ‘exhausted immune response’ class that was characterised by tumour promoting signals such as activated stroma, T-cell exhaustion and immunosuppressive components especially TGF-β (i.e., I–E) [81].