A meta-analysis of 23 studies on the effect of tumour infiltrating lymphocyte (TILs) on the prognosis in HCC patients concluded that high levels of CD8+ and CD3+ TILs improved OS and that high levels of CD8+, CD3+ and CD4+ TILs were linked to improved disease-free survival/recurrence-free survival. This evidence concerns the gene CD8A and neoplasm.