VEGFA and hepatocellular carcinoma: In a global phase 3 clinical trial, atezolizumab (PD-1 inhibitor) was administered alongside bevacizumab (VEGF inhibitor) to patients with unresectable HCC and the combination therapy had better OS at 12 months (67.2% vs. 54.6%) and median progression-free survival (6.8 vs. 4.3 months) than patients given sorafenib only [18].