IL4 and neoplasm: Ethanol intervention promoted the mRNA expression of epithelial-mesenchymal transition (EMT) biomarkers, such as E-cadherin, Snail, MMP-9, and also favored M2 polarization of tumor-associated macrophages by upregulating IL-4, IL-10, CD206, CXCL2, and CCL22, and downregulating IL-12 mRNA (Figure 4B).