The xenografts mouse models comprise injection of human HCC cells or transplantation of fresh PDX into immunodeficient animals, such as non-obese diabetic/severe combined immunodeficiency (NOD-scid) and athymic Balb/c nude mice, delivering a translational model of HCC that recapitulates some of the relevant genetic alterations, i.e., TP53, FGFR1, and KRAS mutations [16,17,18,19]. This evidence concerns the gene TP53 and hepatocellular carcinoma.