ESRRA and hepatocellular carcinoma: In accordance with these findings, estrogen-related receptor-α (ERR-α) KO mice enhanced DEN-induced hepatocarcinogenesis in a neonatal mice model, increasing the incidence (100 and 25%, respectively) and multiplicity (~7 and ~2 tumor/liver, respectively) of tumors, in comparison to wild-type mice, attesting that ERR-α KO mice are susceptible to HCC initiation and progression.