Moreover, in DHN strain, which is originated by inbreeding of Donryu colony, the Drh2 cluster located in rat chromosome 4 was closely associated by mapping analysis to suppression of (pre)neoplastic lesions during chemically induced hepatocarcinogenesis, controlling the expansion of GST-P positive foci and the emergence of HCC [152,153]. This evidence concerns the gene GSTP1 and hepatocellular carcinoma.