On the other hand, APA patients with ATPase mutations are frequently middle-aged men, with hypokalemia and low-renin hyperaldosteronism as well as increased aldosterone responsiveness upon ACTH stimulation, without large adrenal tumors upon CT scan but with histologically well-circumscribed tumors with compact eosinophilic cells and peritumoral hyperplasia [8,24,25]. This evidence concerns the gene POMC and Hypokalemia.