Hypothetically, RTI-positive CS I seminomas expressing increased levels of 14-3-3γ may have poorer prognosis in terms of weak response to CDDP-based chemotherapy compared to -negative cases, due to the coincidental loss of p53, which may be a consequence of action of TAB1-mediated lowered E3 ligase activity of MDM2. The gene discussed is TAB1; the disease is seminoma.