Interestingly, (i) while ezrin displayed cytoplasmatic staining in RTI-negative CS I seminomas, it stained -positive tumours in membranes, (ii) filamin A expression level was higher in the preneoplastic structures (intratubular germ cell neoplasia; IGCN) than in normal tubules (Figure 2A) and (iii) expression of all examined proteins in IC was nearly identical in both CS I seminoma groups (Figure 2B,C). The gene discussed is FLNA; the disease is neoplasm.