TIGAR and breast cancer: This may be due to P53 stimulation, which induces the transcription of the TIGAR gene, which lowers the fructose-2,6-bisphosphate (F-6-bP) and thus decreases glycolysis, mitochondrial ATP production, and overall levels of ROS, suggesting that DDM/or RT is a promising anticancer strategy through the targeting of OXPHOS in BC cells.