AKT1 and cancer: Recent studies indicated that the tumor suppressor, P53, phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), mammalian target of rapamycin (mTOR), nuclear factor-κ light chain enhancer of activated B cells (NF-κB), and vascular endothelial factor (VEGF) pathways are mutated and related to a wide variety of cancer cell phenotypes, including uncontrolled proliferation, genomic instability, and metabolic reprogramming [6].