DDX3X and cancer: Based on these promising observations, in the present work, we developed novel DDX3X helicase inhibitors focusing our attention on the substitutions of triazole, tolyl, and central phenyl rings of the hit compound 1, and after confirming the helicase inhibitory activity of the novel compounds, we screened them against a small panel of cancer cell lines, identifying potent inhibition growth (IG) on GBM cell lines.