In this work, we analysed the diagnostic value of a panel of biomarkers, namely Hb, M2-PK, MMP-2, MMP-9, IL-6, and TNF-α for CRC detection in stool samples from patients with CRC, advanced adenoma, and other lesions, as well as healthy patients as controls. The gene discussed is GSTM1; the disease is colorectal carcinoma.