CDH1 and Hereditary breast cancer: The cumulative risk of lobular breast cancer in the female carriers of pathogenic CDH1 variants by age 80 years is 39–55%, with the average age of diagnosis being 53 years, while the cumulative risk of diffuse gastric cancer in male and female carriers of such variants is approximately 33–42% [157], with a median age of onset of 38 and the youngest reported case aged only 14 at diagnosis.