The tool does not include information related to syndromic causes of breast cancer, precluding use of this tool to generate risk estimates in the known carriers of pathogenic variants in CDH1, PTEN, TP53, or STK11. In order to identify the carriers of such variants, the clinician should be alert to the phenotypes associated with rare syndromic causes of breast cancer. This evidence concerns the gene CDH1 and breast carcinoma.