The BRCAPRO model is a Bayesian tool that incorporates information regarding population frequencies of pathogenic variants in BRCA1 and BRCA2, penetrance estimates, as well as personal and family history of cancer—including data related to unaffected as well as affected relatives—to generate estimates of breast cancer risk as well as the probability of identifying a high-risk germline variant [271]. The gene discussed is BRCA2; the disease is breast cancer.