Several pathways, including the JAK-STAT [27,28,29], Hedgehog [30,31,32], β-catenin [33,34,35,36], and PI3K [37,38,39] pathways, have been reported to be involved in the therapy resistance of CML stem cells. Here, SOAT1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.