For instance, the pancreatic ductal cell line, PANC-1, derived from a QM-type adenocarcinoma, is the only pancreatic cancer cell line for which transdifferentiation into endocrine precursors with NGN3 activation [6,13] or β cell-like cells [14,15,16,17,18,19,20,21,22] has been reported. This evidence concerns the gene NEUROG3 and pancreatic neoplasm.