CADM1 has been shown to interact with T-lymphoma invasion and metastasis 1 (Tiam1) via the cytoplasmic domains and induces the formation of lamellipodia through Rac activation, thus enhancing migration and tissue infiltration of HTLV-1-infected T cells and ATLL cells [126] (Figure 3). The gene discussed is CADM1; the disease is adult T-cell leukemia/lymphoma.