ACE and hypertensive disorder: Once hypertension (>140/90 mmHg) or an increase in diastolic BP greater than 20 mmHg over baseline has developed [33], angiotensin-converting enzyme inhibitors (ACEi) or angiotensin II receptor blockers (ARB) should be considered first, followed by calcium channel blockers, diuretics/thiazides, and β-adrenoceptor blockers if required, either as monotherapy or in combination [34,35,36].