Knockdown of LGALS1 in glioma cells indicated that Gal-1 controls multiple genes related to motility and migration, including genes encoding CapG and Map-2, two regulators of actin cytoskeleton dynamics, cadherin 6, as well as other proteins, such as Adam15, is known to interact with α9β1 integrin to modulate intercellular adhesion and cellular invasiveness [23,24,25,26]. This evidence concerns the gene LGALS1 and central nervous system cancer.