The role of Gal-1 in promoting the invasiveness of glioma cells is not restricted to its intracellular functions, as other reports have shown that Gal-1 can promote cell invasion by promoting the adhesion of cells to proteins of the extracellular matrix, such as fibronectin and laminin, and to cell surface β1 integrins [28,29,30,31]. Here, LGALS1 is linked to central nervous system cancer.