ZEB1 and neoplasm: Lineage-tracing experiments on both those mouse strains, which fully recapitulate tumor histology, desmoplastic stroma, and metastatic spread in humans, revealed the expression of EMT transcription factor Zeb1 in areas of acinar-to-ductal metaplasia (ADM) as well as in cells of pre-invasive lesions of low and high grade PanIN [72].