In the cases of oral squamous cell carcinoma and pancreatic ductal adenocarcinoma, the alteration of E-cadherin expression is accompanied by a simultaneous increase in the levels of EMT transcription factors Zeb1 and Zeb2 within tumor buds [47,48,49,50,51,52,53,54]. Here, CDH1 is linked to pancreatic ductal adenocarcinoma.