CDH1 and pancreatic ductal adenocarcinoma: Consistent with the potential link between EMT and tumor budding, immunohistochemical studies of specimens from a variety of epithelial tumors, including oral squamous cell, esophageal and endometrial carcinoma, as well as colorectal and pancreatic ductal adenocarcinoma, have revealed reduction or complete abolishment of E-cadherin expression.