In addition, the Ephrin-B3 (EFNB3) gene has been demonstrated to be a direct target of miR-204 [144], although its significance in NB is unclear as EFNB3 expression is directly correlated with a favorable NB prognosis, while in miR-204 downregulation is associated with opposite effects [40]. The gene discussed is EFNB3; the disease is neuroblastoma.