The MES-specific CRC includes the TFs PRRX1, TWIST1, SNAI2 and MAML3; NOTCH members RUNX1, NFKB and AP-1; TF family members (including JUN and FOS family members), the retinoic acid receptor beta RARB and many others [41,42,50,52,55]. This evidence concerns the gene TWIST1 and colorectal carcinoma.