A genome-wide ChIP-Seq analysis detected a small number of transcription factors such as MYCN, HAND2, ISL1, PHOX2B, GATA3 and TBX2 belonging to the ADRN CRC that are essential for cell state and survival and represent dependencies in MYCN-amplified NB [51]. This evidence concerns the gene PHOX2B and colorectal carcinoma.