TWIST1 directly activates its TGs by promoter binding, including PRRX1 (Figure 4), but also specifies other TGs relying on other cues, including potentially MYCN, to enforce transcriptional activation or repression by enhancer co-occupancy, therefore, it can be considered a deregulated MYCN-specific dependency in NB [7]. The gene discussed is TWIST1; the disease is neuroblastoma.