For example, altered MYCN influences cytotoxic drug response in NB via regulation of the multidrug resistance-associated protein (MRP) gene expression, so that MYCN overexpression increases MRP expression and the resistance specifically to MRP drug substrates, while downmodulation of MYCN lowers MRP expression and significantly increases sensitivity to the high affinity MRP substrates [198]. Here, MYCN is linked to neuroblastoma.