Interestingly, as we have demonstrated that PHOX2B drives ALK gene transcription (Figure 3) by directly binding its promoter, this regulatory relationship explains the co-overexpression of the two genes found in NB samples and NB cell lines [26,219,222] due to the downstream effect of PHOX2B overexpression in enhancing ALK transcription, underlying their functional cooperation in initiating and worsening NB pathogenesis. The gene discussed is PHOX2B; the disease is neuroblastoma.