In vivo studies have shown that Notch2 NICDs expressed in NSCs promote proliferation and prevent neuronal lineage entry, thus suggesting that Notch2 plays a role in NB pathogenesis; such a hypothesis is supported by the observation that miR-204 is a negative regulator of tumor invasion and its upregulation inhibits cancer cell proliferation by targeting Notch2 mRNA [156], as confirmed by the fact that depletion of miR-204 by BANCR-mediated sponging contributes to the growth and invasion of melanoma through Notch2 upregulation [157]. The gene discussed is NOTCH2; the disease is neoplasm.