The identified ADRN-specific CRC includes important TFs like PHOX2A, PHOX2B, ASCL1, HAND2, GATA2, GATA3, LMO1, TBX2, ISL1 and many others; the tyrosine kinase receptor ALK; and DBH and TH enzymes involved in the metabolism of catecholamines. This evidence concerns the gene ISL1 and colorectal carcinoma.