Physiologically, these miRNAs downmodulate MYCN and PHOX2B and, directly or indirectly, the expression of their targets ALK and LIN28B within a network of regulatory feedback and coherent feedforward loops (Figure 3) that are disrupted in NB, thereby generating a loss of inhibitory functions and aberrant transcription activations (Figure 4). This evidence concerns the gene LIN28B and neuroblastoma.