In another study, using JoMa1, a murine multipotent NC progenitor cell line, immortalized with Tamoxifen-inducible Myc-ERT, it has been demonstrated that NC progenitor cells give rise to NB in vivo upon transformation with enforced expression of MYCN or ALK (p.F1174L) [245]. This evidence concerns the gene MYCN and neuroblastoma.