TP53 and neoplasm: MYCN can activate the transcription of a great number of TGs, among which CDK4, CHK1, ID2, MCM, MYBL2 and SKP2 promote cell proliferation, MDM2 and TRKB sustain cell survival, TWIST1 sustains cell survival and promotes EMT, genes encoding the cell cycle-regulated kinase AURKA promote tumor development and progression, FAK and integrins are involved in migration and metastasis spread, BMI1 and DLL3 hold self-renewal, VEGF boosts angiogenesis, KLF2, KLF4, and SSEA-1 maintain pluripotency, as does TP53 and consequent TP53-driven apoptosis [162].