MYCN and neuroblastoma: Upon MYCN overexpression in a MYCN-inducible NB cell line, several differentiation-relevant genes, including LMO4, CYP26A1, ASCL1, RET, FZD7 and DKK1, and a broad network of transcriptional regulators involved in regulating retinoid responsiveness, such as Neurotrophin, PI3K, Wnt and MAPK, have recently been identified [174].