Among the pathways involved in the differential regulation of MYC proteins during embryonic organogenesis, Sonic hedgehog (Shh) signaling, which plays a key role in cancer and chemo-resistance, activates MYCN, while the Wnt/beta-catenin pathway, promoting stem cell regeneration and cell survival in cancer, activates c-MYC [176]. The gene discussed is CTNNB1; the disease is cancer.