We illustrate, as an example, how overexpressed MYCN is able to co-occupy/invade either enhancers or SEs in ADRN CRC (Figure 7A), leading to enhancer/SE-driven transcription activation of PHOX2B (Figure 7B) and of the other TFs belonging to the ADRN CRC. Here, PHOX2B is linked to colorectal carcinoma.