In the adjuvant setting of UC, the IMvigor 010 with the anti-PD-L1 atezolizumab did not show a significant advantage in DFS compared to observation either in patients with positive PD-L1 tumours IC according to the SP142 Ventana assay, or in the overall population [54], while the Checkmate274 showed a significant DFS advantage in favour of nivolumab versus observation in the intention-to-treat population with a better HR in patients with a PD-L1 expression ≥ 1% (HR 0.55 vs. 0.70 for the overall population), as assessed on TC by a PD-L1 IHC 28-8 pharmDx assay [55]. Here, CD274 is linked to neoplasm.