TP53 and Miyoshi myopathy: However, when tested in multivariate analysis, even these combinations lost their independence in predicting poorer OS compared to other variables, as 1q gain/amplification alone or combined with TP53 alterations, age equal to or over 65 years, and ISS stages III and I. Overall, our present data suggest that MIAT expression levels cannot be considered an independent prognostic marker in MM.