Some of these therapies involve targeting integrins; for example, ibrutinib (pharmacologic inhibitor of integrin signaling) has been used clinically to treat lymphoid leukemia and lymphoma [41,42], whereas vitaxin, a humanized monoclonal antibody, which has specificity for the integrin alpha v beta 3 (vitronectin receptor) has been used to treat ovarian cancer [43] and other cancers, including metastatic types [44,45]. Here, ITGAV is linked to lymphoid leukemia.