PAX5 is also rearranged in 2.6% of pediatric B-ALL cases, being fused to a wide diversity of fusion partners involving other transcription factors such as ETV6 and FOXP1, chromatin regulators such as NCoR1 and BRD1, a protein kinase such as JAK2 and an estrogen-related receptor such as ESRRB [160,178,179,180,181]. Here, ETV6 is linked to precursor B-cell acute lymphoblastic leukemia.