SF3B1 mutations are found in hematologic malignancies such as myelodysplastic syndrome (MDS), myeloproliferative neoplasms, chronic myeloid leukemia, and acute myeloid leukemia (AML), as well as solid tumors such as uveal melanoma, mucosal melanoma, leptomeningeal melanoma, blue nevus-like cutaneous melanoma, neuroblastomas that arise following chromothripsis, estrogen receptor-positive breast cancer, pancreatic ductal adenocarcinoma, prostate cancer, and prolactinoma [72]. The gene discussed is ESR1; the disease is acute myeloid leukemia.