PRAME and neoplasm: Epithelioid cell type, higher values of mean diameter of ten largest nucleoli, higher microvascular density, extravascular matrix patterns, high mitotic activity, tumor-infiltrating lymphocytes, tumor-infiltrating macrophages, higher expression of insulin-like growth factor-1 receptor, higher expression of human leukocyte antigen Class I and II, MET and PRAME expression are histopathologic features suggestive of poor prognosis [57,91,92].