PHANTM combined phenotype score as a categorical variable, dichotomized at the median (over 1 vs. equal or less than 1), was found to be an independent prognostic factor in the patients with TP53 mutated MDS (HR (95%CI): 1.62 (1.01–2.58, p = 0.044). This evidence concerns the gene TP53 and myelodysplastic syndrome.