They reported that the multi-hit TP53 state (more than one gene mutation, mutation and deletion, mutation and copy-neutral loss of heterozygosity) in MDS underlies established associations with genome instability, treatment resistance, disease progression and dismal outcomes, indicating that consideration of TP53 allelic state is critical for diagnostic and prognostic precision in MDS [33]. The gene discussed is TP53; the disease is myelodysplastic syndrome.