This is supported by the demonstration that Ppm1d-deficient mice show a delayed onset of mammary gland tumor development whereas an accelerated onset of tumors is evident in mice overexpressing PPM1D and ERBB2 in the mammary gland as well as reduced survival of APCmin mice developing colon cancer [27,32,33]. The gene discussed is PPM1D; the disease is malignant colon neoplasm.