In addition to Notch1 and Pten mutations, aberrations in genes previously associated to human cancers were also observed in Ikzf1, Kras, Rac2, Trp53, Ctnnb1, Gli3, Zfp36l2, Mpdz, Dd3x, Foxp1, Pin1, and Ezh2 (Table S1). The gene discussed is CTNNB1; the disease is cancer.