Numerous protein markers are used for the determination of tumor staging, where some include glial fibrillary acidic protein (GFAP), P38, neuromicrofilaments (NF), tumor protein p53 (p53), Bcl2 apoptosis regulator (BCL2), β-tubulin III (TUBB3), RNA binding Fox-1 homolog 3 (Neu-N), β-catenin (CTNNB1), pre-mRNA-splicing factor ini1 (INI1), marker of proliferation Ki-67 (MKI67), keratin, mucin 1 cell surface associated (MUC1 or EMA), epidermal growth factor receptor (EGFR), P27, S100 calcium binding protein (S100), actin, desmin (DES), myelin (MBP), and others. The gene discussed is DES; the disease is neoplasm.