Numerous protein markers are used for the determination of tumor staging, where some include glial fibrillary acidic protein (GFAP), P38, neuromicrofilaments (NF), tumor protein p53 (p53), Bcl2 apoptosis regulator (BCL2), β-tubulin III (TUBB3), RNA binding Fox-1 homolog 3 (Neu-N), β-catenin (CTNNB1), pre-mRNA-splicing factor ini1 (INI1), marker of proliferation Ki-67 (MKI67), keratin, mucin 1 cell surface associated (MUC1 or EMA), epidermal growth factor receptor (EGFR), P27, S100 calcium binding protein (S100), actin, desmin (DES), myelin (MBP), and others. This evidence concerns the gene RBFOX3 and neoplasm.