TNF and metastatic malignant neoplasm in the lymph nodes: In the multivariate analysis, they found that the statistically significant predictive factors for the complete response were: a total number of metastases less than ten [27,29,33], a longer perfusion time (120 min) under mild hyperthermia (39–40 °C) [29], TNF dose [34,35], age < 65 years [34], and the absence of lymph node metastases [37,43] or at stage IIIB or less [34].