In lung cancer cells, STAT3 functions as a tumor suppressor by sequestering NF-κB within the cytoplasm and preventing it from transcribing IL-8. Because IL-8 is critical in recruiting suppressive myeloid cells and promoting tumor vascularization, loss of STAT3 results in enhanced IL-8 secretion and lung cancer progression [125]. This evidence concerns the gene NFKB1 and neoplasm.