PTPN11 and Miyoshi myopathy: Moreover, Chong and colleagues reported that IL-6 mediated STAT3 activation led to the transcriptional activation of PRL-3 (an oncogenic phosphatase overexpressed in MM) and PRL-3 increased the rephosphorylation of STAT3 via the direct interaction and deactivation of SHP2 forming a feedforward loop in MM [83].