ERBB2 and breast cancer: Connolly et al. used a methylation panel, which investigated 10 genes (HIST1H3C, AKR1B1, GPX7, HOXB4, TMEFF2, RASGRF2, COL6A2, ARHGEF7, TM6SF1, and RASSF1A), to evaluate tumor tissue and serum samples from patients with HER2-negative BC.