Recent studies published in Nature reported that in nonalcoholic steatohepatitis-related hepatocellular carcinoma (NASH-HCC) mouse models, resident-like CXCR6-positive and CD8-positive cells were activated rather than T-cells through MHC class 1 molecule antigen presentation, which promoted a poor immunotherapy response [75,76]. This evidence concerns the gene CD8A and hepatocellular carcinoma.