ERBB2 and breast cancer: Everolimus is FDA-approved for five cancerous conditions including advanced RCC (2009), subependymal giant cell astrocytoma associated with tuberous sclerosis (2010), progressive neuroendocrine tumours of pancreatic origin (2011), advanced hormone receptor-positive HER2-negative breast cancer (2012), paediatric and adult patients with subependymal giant cell astrocytoma (2012), and neuroendocrine tumours of gastrointestinal or lung origin with unresectable, locally advanced or metastatic disease (2016).