Immunoscore (IS) is a digital pathology diagnostic test that measures the host immune response at the tumor site through the automated quantitation of CD3+ and CD8+ tumor-infiltrating lymphocytes (TILs) at the invasive margin and tumor core, providing scores ranging from low (IS 0–1) to high (IS 2–4) [21,22]. The gene discussed is CD8A; the disease is neoplasm.