Here, a blockade of pancreatic tumor cell-derived CD95L using pharmacological inhibitor sCD95Fc showed considerable reduction in the expression of tumor-promoting genes, including PICs (Figure 7) and TAPs (Supplementary Figure S5) induced upon TNF-α or TRAIL stimulation in a time and concentration-dependent manner in both PDAC cell lines. The gene discussed is TNF; the disease is pancreatic neoplasm.