Studies in the past several years have established that the cytokine CD95L member of the TNF superfamily, including TNF-α and TRAIL, plays a crucial role in the progression of tumor growth and metastatic spread through increased production of PIC and CSC (phenotypes) markers as well as activation of NFκB in PDAC [19,21,22,23,44,45]. Here, TNFSF10 is linked to neoplasm.