TNF and neoplasm: Moreover, the blockade of CD95L not only suppresses the gemcitabine-mediated tumor-promoting functions but also sensitized PDAC cells towards gemcitabine-induced cell death by diminishing the pro-inflammatory signaling of TNF-α and TRAIL in a bi- or tri-lateral crosstalk manner (Figure 2, Figure 3 and Figure 5, Figure 6 and Figure 7).