Thus, these findings indicate that there might be a proteolytic cleavage of TNF-α and/or TRAIL-induced mCD95L by metalloproteinases (MMP2, MMP7, ADAM10) and thus, these cleaved or soluble forms of sCD95L might be linked with increased tumor growth and metastasis in an NFκB-dependent manner [51,52]. This evidence concerns the gene TNFSF10 and neoplasm.