BRAF and cutaneous melanoma: Unlike cutaneous melanoma, which has driver mutations in v-raf murine sarcoma viral oncogene homolog B1 (BRAF), neuroblastoma RAS viral oncogene homolog (NRAS), and neurofibromatosis type 1 (NF1), more than 90% of UM cases commonly harbor mutations in the alpha subunit of heterotrimeric G proteins, GNAQ/GNA11, that are involved in early UM development.