In support, particularly high TCL1A levels are observed in the aggressive subsets of CLL that are characterized by chromosomal losses at 11q22 (ATM) [28] and 17p (TP53) [29], with a suggested codeletion of TCL1A repressive miR-34b-5p [90] and tRNA-derived small RNA (tsRNA)-3676 (before known as miR-3676) [89], respectively. Here, TCL1A is linked to B-cell chronic lymphocytic leukemia.