With this as a background, given the interaction of the signal pathways mediated by RAS with HSP70/HSF1 and supported by the study of Mustafi et al. on CML cells [17], we used resveratrol, a natural polyphenol equipped with anti-cancer properties through the modulation of different kinases (e.g., Akt and Erk1/2) and transcription factors (e.g., Nf-kB [41]). Here, HSF1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.