DNMT1 and neoplasm: LMP1 transcriptionally upregulates the DNA methyltransferase I (DNMT1) and potentiates its activity [139], and in turn, DNMT1 and its partner UHRF1 restricts the expression of LMPs and EBNAs through CIMP [140], in addition to a pool of cellular tumor-suppressor genes as week as B-cell activation antigens that are also downregulated through CIMP [141].