In HCC, inhibition of Axl activates cell cycle checkpoint kinases Chek1/2 and cyclin dependent kinases CDK1/2, thus explaining the sensitivity of HCC cell lines to combinatory inhibition of EMT kinome (including NUAK1/2 and Axl) and check point/DDR blockade [61]. This evidence concerns the gene NUAK1 and hepatocellular carcinoma.